abstract：:The aim of this study was to gauge the possible sprouting of primary afferent fibers following dorsal rhizotomies using Fos-like immunoreactivity (Fos-LI) in order to label neurons activated by formalin injection into the rat forepaw. To assess the functional consequences of possible sprouting of fine diameter primary...

journal_title：Restorative neurology and neuroscience

authors： Abbadie C,Lombard MC,Morain F,Besson JM

更新日期：1994-01-01 00:00:00

abstract：:The antagonizing effect of the β-adrenoceptor antagonist propranolol (PRP) on the desipramine (DMI)-induced regeneration of brain noradrenergic fibers was examined. The symmetrical sites of the rat frontal cortex were pretreated with 6-hydroxydopamine (6-OHDA). Then, the same cortical site of one hemisphere was infuse...

journal_title：Restorative neurology and neuroscience

authors： Nakamura S

更新日期：1994-01-01 00:00:00

abstract：:While the regenerating capacity of peripheral nerves has been the subject of intensive study, little is known about the regenerative capacity of the autonomic nervous system. Using an animal model, where the pupil diameter of the eye in the rat serves as a parameter of autonomic function, we studied whether systemic t...

journal_title：Restorative neurology and neuroscience

authors： Vandertop WP,de Vries WB,Notermans NC,Tulleken CA,Gispen WH

更新日期：1994-01-01 00:00:00

abstract：:Fetal cerebral cortical tissue was transplanted into an aspirated lesion cavity made in the sensorimotor cortex of adult rats. Ten weeks after grafting, outgrowing fibers from the graft were visualized by an anterograde tracing technique using Phaseolus vulgaris leucoagglutinin (PHA-L). It was demonstrated that the ef...

journal_title：Restorative neurology and neuroscience

authors： Senatorov VV,Nyakas C,Fulop Z

更新日期：1993-01-01 00:00:00

abstract：:The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...

journal_title：Restorative neurology and neuroscience

authors： Hori Y,Kageyama H,Kihara T,Ikeda M,Nakano A,Kurosawa A

更新日期：1993-01-01 00:00:00

abstract：:In rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons ( + 24%) up to day 3 post le...

journal_title：Restorative neurology and neuroscience

authors： Vergara J,Medina L,Maulén J,Inestrosa NC,Alvarez J

更新日期：1993-01-01 00:00:00

abstract：:The outgrowth of neurites in neuronal cell cultures reflects the intrinsic capacity for neurite regeneration and morphological rearrangements after axotomy and in plasticity. The role of fast axonal transport in these neurite outgrowth responses has not been investigated. We have recently shown that sabeluzole (R58735...

journal_title：Restorative neurology and neuroscience

authors： Geerts H,Nuydens R,Nuyens R,Cornelissen F

更新日期：1992-01-01 00:00:00

abstract：:IVth International Symposium on Neural TransplantationEdited by William J. Freed and Jeffrey M. RosensteinThe George Washington University, Washington, DC, USAJuly 12-16, 1992. ...

journal_title：Restorative neurology and neuroscience

authors：

更新日期：1992-01-01 00:00:00

abstract：:Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-section...

journal_title：Restorative neurology and neuroscience

authors： Ribarič S,Jarh O,Sepe A,Demsar F

更新日期：1992-01-01 00:00:00

abstract：:Vestibular habituation was studied in normal subjects and in patients with cerebellar disease using a stimulation paradigm proposed in this paper. Six caloric stimuli were repeated daily in the same ear during six days and electronystagmographic responses at the beginning and the end of that period were compared. The ...

journal_title：Restorative neurology and neuroscience

authors： Suarez H,Caffa C,Macadar O

更新日期：1992-01-01 00:00:00

abstract：:Granule cells of the dentate gyrus can be selectively destroyed by intrahippocampal injections of colchicine. The present study evaluates the consequences of this selective neuronal destruction on the afferent axon terminals which have been deprived of their normal targets. The area of the neuropil in the dentate gyru...

journal_title：Restorative neurology and neuroscience

authors： Goldschmidt RB,Steward O

更新日期：1992-01-01 00:00:00

abstract：:We have tested the capacity of several compounds with in vitro and/or in vivo antioxidant or antilipolytic activity to ameliorate locomotor function in cats subjected to static loading (i.e. compression) injury of the spinal cord. These include the synthetic glucocorticoid, methylprednisolone sodium succinate (MP), an...

journal_title：Restorative neurology and neuroscience

authors： Anderson DK

更新日期：1991-01-01 00:00:00

abstract：:Portions of 1 cm length of the sensory radial nerve from the cat forelimb were used to replace an excised portion of the dorsal columns in the upper lumbar spinal cord. Observations were made on the clinical recovery of the animals, and cine recordings were made of their ability to traverse a horizontal ladder 5 month...

journal_title：Restorative neurology and neuroscience

authors： Wilson DH

更新日期：1991-01-01 00:00:00

abstract：:The mechanisms underlying recovery of function following damage to the CNS, although suspected, are virtually unknown. After damage to the adult cat spinal cord, recovery of motor behavior depends on which systems have been interrupted and which remain intact. For example, following hemisection, overground (voluntary)...

journal_title：Restorative neurology and neuroscience

authors： Goldberger ME

更新日期：1991-01-01 00:00:00

abstract：:Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...

journal_title：Restorative neurology and neuroscience

authors： Sprick U

更新日期：1991-01-01 00:00:00

abstract：:We are interested in the role cyclic AMP may play as a mediator of growth factor-induced gene expression in regenerating peripheral nerves. As a first step, we investigated mRNA levels and protein synthesis in intact frog dorsal root ganglia (DRG) treated with the adenylate cyclase activator, forskolin in vitro. Forsk...

journal_title：Restorative neurology and neuroscience

authors： Carlsen RC,De Leon M,Tetzlaff W,Parhad IM,Bisby MA

更新日期：1990-01-01 00:00:00

abstract：:Injuries to peripheral nerves represent a challenging clinical problem. In spite of the use of microsurgical techniques, repair of severed nerves seldom results in complete recovery of motor and sensory functions. Misdirection of axons at the suture line as well as a slow axonal outgrowth contribute to the bad results...

journal_title：Restorative neurology and neuroscience

authors： Lundborg G

更新日期：1990-01-01 00:00:00

abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...

journal_title：Restorative neurology and neuroscience

authors： Rosen JM,Grosser M,Hentz VR

更新日期：1990-01-01 00:00:00

abstract：:In the present study, we have developed an animal model for central nervous system (CNS) damage using the graded crush injury of the adult rat optic nerve. This injury model has the following characteristics: (a) the injuries are reproducible; (b) the injuries can be created with controlled severity; and (c) variation...

journal_title：Restorative neurology and neuroscience

authors： Duvdevani R,Rosner M,Belkin M,Sautter J,Sabel BA,Schwartz M

更新日期：1990-01-01 00:00:00

abstract：:Wound-derived trophic factors released by the injured brain are thought to reach a peak 1-2 weeks after injury. It has been proposed that such factors can promote the survival, growth and functional capacity of embryonic tissue grafts. To test the generality of this hypothesis, control rats and rats with aspirative fi...

journal_title：Restorative neurology and neuroscience

authors： Dunnett SB,Martel FL,Rogers DC,Finger S

更新日期：1989-01-01 00:00:00